gset: An R Package for Exact Sequential Test of Equivalence Hypothesis Based on Bivariate Non-Central t-Statistics

Abstract:

The R package gset calculates equivalence and futility boundaries based on the exact bivariate non-central t test statistics. It is the first R package that targets specifically at the group sequential test of equivalence hypotheses. The exact test approach adopted by gset neither assumes the large-sample normality of the test statistics nor ignores the contribution to the overall Type I error rate from rejecting one out of the two one-sided hypotheses under a null value. The features of gset include: error spending functions, computation of equivalence boundaries and futility boundaries, either binding or nonbinding, depiction of stagewise boundary plots, and operating characteristics of a given group sequential design including empirical Type I error rate, empirical power, expected sample size, and probability of stopping at an interim look due to equivalence or futility.

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Author

Affiliation

Fang Liu

 

Published

Jan. 3, 2015

Received

Aug 16, 2014

DOI

10.32614/RJ-2014-033

Volume

Pages

6/2

174 - 184

CRAN packages used

gsDesign, GroupSeq, Hmisc, PwrGSD, AGSDest, clinfun

CRAN Task Views implied by cited packages

ClinicalTrials, ExperimentalDesign, Bayesian, Econometrics, Multivariate, OfficialStatistics, ReproducibleResearch, SocialSciences, Survival

Footnotes

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    Citation

    For attribution, please cite this work as

    Liu, "The R Journal: gset: An R Package for Exact Sequential Test of Equivalence Hypothesis Based on Bivariate Non-Central t-Statistics", The R Journal, 2015

    BibTeX citation

    @article{RJ-2014-033,
      author = {Liu, Fang},
      title = {The R Journal: gset: An R Package for Exact Sequential Test of Equivalence Hypothesis Based on Bivariate Non-Central t-Statistics},
      journal = {The R Journal},
      year = {2015},
      note = {https://doi.org/10.32614/RJ-2014-033},
      doi = {10.32614/RJ-2014-033},
      volume = {6},
      issue = {2},
      issn = {2073-4859},
      pages = {174-184}
    }