CRTgeeDR: an R Package for Doubly Robust Generalized Estimating Equations Estimations in Cluster Randomized Trials with Missing Data

Abstract:

Semi-parametric approaches based on generalized estimating equations (GEE) are widely used to analyze correlated outcomes in longitudinal settings. In this paper, we present a package CRTgeeDR developed for cluster randomized trials with missing data (CRTs). For use of inverse probability weighting to adjust for missing data in cluster randomized trials, we show that other software lead to biased estimation for non-independence working correlation structure. CRTgeeDR solves this problem. We also extend the ability of existing packages to allow augmented Doubly Robust GEE estimation (DR). Simulation studies demonstrate the consistency of estimators implemented in CRTgeeDR compared to packages such as geepack and the gains associated with the use of the DR for analyzing a binary outcome using a logistic regression. Finally, we illustrate the method on data from a sanitation CRT in developing countries.

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Published

Aug. 24, 2017

Received

Nov 16, 2016

DOI

10.32614/RJ-2017-041

Volume

Pages

9/2

105 - 115

CRAN packages used

CRTgeeDR, gee, geepack, geeM, ipw, drgee, CausalGAM, tmle, tmlenet, numDeriv, geesmv

CRAN Task Views implied by cited packages

SocialSciences, Econometrics, NumericalMathematics, Robust

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    Citation

    For attribution, please cite this work as

    Prague, et al., "The R Journal: CRTgeeDR: an R Package for Doubly Robust Generalized Estimating Equations Estimations in Cluster Randomized Trials with Missing Data", The R Journal, 2017

    BibTeX citation

    @article{RJ-2017-041,
      author = {Prague, Melanie and Wang, Rui and Gruttola, Victor De},
      title = {The R Journal: CRTgeeDR: an R Package for Doubly Robust Generalized Estimating Equations Estimations in Cluster Randomized Trials with Missing Data},
      journal = {The R Journal},
      year = {2017},
      note = {https://doi.org/10.32614/RJ-2017-041},
      doi = {10.32614/RJ-2017-041},
      volume = {9},
      issue = {2},
      issn = {2073-4859},
      pages = {105-115}
    }